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Concentrate for preparation of infusions solution

«Fotoditazin®» concentrate for preparation of infusions solution.

Pharmaterapeutic photosensitizer.

Pharmacological properties

Pharmacodynamics. Fotoditazin® is the photosensitizer of the second generation intended for fluorescent diagnostics (FD) and photodynamic therapy (PDT) of malignant tumours.

The preparation selectively accumulates in malignant neoplasms. At the subsequent irradiation of the tumoral center by monochromatic light of 661 - 662 nanometers wave length arises photosensitizing effect consisting in generation of active forms of oxygen in a tumoral tissue (singlet oxygen) and other free radical particles leading to the development of biochemical and structurally functional changes in cells of a tumour and their destruction. High photocytotoxicity of Fotoditazin® is characteristic for various kinds of tumoral cells. Fotoditazin is the high-quality diagnostic means within spectrofluorescent methods of research.
The specified features of the preparation practically exclude damaging action, at carrying out PDT, healthy bodies and tissues, and also integuments traumatizing by the light.

Pharmacokinetics. After intravenous induction of fotoditazin the maximal concentration in a tumour is reached in 1,5-2,5 hours from the moment of induction (depending on nosological type of a tumour). In 4-5 hours concentration of fotoditazin in a tumour gradually decreases. The period of preparation half-elimination - 12 hours. In 28 hours after intravenous induction, in blood are found out trace quantities of the preparation. The maximal factor of preparation accumulation contrast (a tumour/normal tissue) depends from nosological type of tumour and can vary from 3,0 up to 24.
Preparation actively metabolizing in a liver (over 95 %).
Connection with fibers of plasma makes 92-96 %.

Indications to application

Fluorescent diagnostics of skin cancer and cancer of lung. Photodynamic therapy of a skin cancer (planocellular, basal - cellular), cancer of lung (only in case of presence of contra-indications to operative treatment).


The high sensitivity to the preparation.
Expressed renal or hepatic insufficiency.
Cardiovascular diseases in a decompensation phase.
Pregnancy and the lactation period.

Collateral action

Temperature rise (37-38 ºС) within 30 minutes, and pain in the zone of irradiation which are stoped by introduction of analgesics, antihistaminic means. Increase of patients arterial pressure accompanying diseases of cardiovascular system.

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Tumor fragment surrounded by healthy tissue cells
PHOTODITAZINE injection. Selective accumulation in tumor
Affected tissue irradiation with long-wave red radiation
Reactive oxygen species formation. Induction of necrosis in tumor cells
Selective death of tumor cells surrounded by healthy tissue