Orthopedics

PHOTODYNAMIC THERAPY OF INFLAMMATORY ARTHRONOSOS IN CHILDREN AND ADOLESCENTS


Indications:
  • Juvenile chronic arthritis
  • Juvenile rheumatoid arthritis


In several healthcare settings of Russia is conducted experimental and clinical potency assignment of photodynamic therapy with the topical agent Fotoditazin in traumatology and orthopedics.

In the process of work developed and refined techniques of photodynamic therapy with the topical agent Fotoditazin ( gel penetrator for external application ) for injuries and degenerative - dystrophic damage of the knee, shoulder and wrist joints.

Traumatology

PHOTODYNAMIC THERAPY with the drug "FOTODITAZIN is successfully used in combination treatment of the following cases:

  • decubituses
  • firearm wound of soft tissues
  • trophic ulcers
  • septic wounds
  • persistent wounds


Treatment of these injuries cause considerable difficulties and demands application systemic and topical agents of different pharmacological groups. Technical simplicity of performance, pathogenetic validity and high efficiency distinguish PDT in comparison with traditional treatments.

According to clinical, planimetric and morphological studies of PDT with the gel "FOTODITAZIN for the treatment of ulcers promotes acceleration of wound cleansing from the devitalized tissue, normalization of microcirculatory disorders , enhancement phagocytosis , pacing of fibroblast proliferation , maturation of granulation tissue and epithelialization of the ulcer.

ombination treatment of patients with persistent wounds using high-energy laser radiation, laser photodynamic therapy, cold laser therapy and biologically active wound coverings according to clinical , pathophysiological , cytological, histological, microbiological and biophysical studies is pathogenetically proved and highly effective and by 1,5 - 2 times reduces terms of scarring and epithelialization persistent wounds.

Stomatology

igh anti-microbial efficiency of photodynamic therapy and increase of nonspecific resistance of an organism are revealed in recent years. These facts form the basis for the use of this method in dentistry, particularly in periodontology, in endodontology and for treatment of dental caries. Ministry of Health and Social Development of the Russian Federation approved and allowed the wide spread use in medical practice, the following medical technologies which employ in stomatology the topical agent Fotoditazin :

PHOTODYNAMIC THERAPY OF PERIODONTIUM DISEASES

Indications:
  • Periodontitis of different severity
  • Gingivitis and inflammation of mucousa of oral cavity
  • Intolerance of medical agents
  • Patients refusal from conventional therapy



The essence of a method consists in destruction of cages of pathogenic microflora and pathologically changed tissues of paradontium after their interaction with the preparation "FOTODITAZIN" and then monochromatic medical laser irradiation which processed by a preparation "FOTODITAZIN".

Clinical trials confirmed efficiency of FDT with the preparation "FOTODITAZIN in the following cases:

  • peri-implant pathology
  • bacterial and mycotic lesion of an oral cavity (stomatitis, etc.)
  • treatment of dental caries
  • sterilization of alveolar canals
  • tooth whitening


Stomatology

After using of the preparation "FOTODITAZIN disappear symptoms of inflammation, healing is accelerated and starkly the tissue immunity is increased, pain decreases.

Advantage of photodynamic influence is the possibility of local selective destruction of microbial cells arranged as surfactants and in the intercellular spaces without side effects on surrounding tissues and micro flora adjacent zones. It was a basis of a method for treating diseases of the oral mucosa.

The most optimal for the treatment of antiseptic preparation (canals radices) of teeth for use in clinical practice is used of photodynamic therapy with an time of an exposure 60 seconds.

For use of method of photodynamic therapy in the treatment of dentine caries ( pulpitis , periodontitis) , it is necessary to use laser light sources with a wavelength of 661-668 nm , output power of 200-300 mW/cm2.

Applying FDT the flexible end of light guide should be at 0.5-1 cm from the bottom of the decay cavity. Accordingly, the end of light guide is site at the disposal of 0.5-1 mm light guide from the top of the canals radices.

After applying photosensitiser in decay cavity (in the canals radices), it should be stay there during 1 minute.

Then we begin to influence on decay cavity (on the canals radices) with decay cavity (in the canals radices), using the laser light during the specified time. After you need carefully rinse mouth cavity (the canals radices) and can enter upon the standard teeth filling (the canals radices) including the functional and esthetic parameters of the particular tooth.

This method is recommended to use in healthcare practice at the outpatient dental visit.

Gynecology

Photodynamic therapy in gynecology

Photodynamic therapy in gynecology has a number of advantages in comparison with other methods (diathermocoagulation, lazerovaparizatsiya, cryodestructions):

It causes the selective death of abnormal cells without damaging healthy tissue, due to the selective accumulation of the photosensitizer in the pathological cells and summing the local light;
  • unpainful during the operation;
  • no bleeding;
  • early onset of boundary epithelization;
  • imperceptible leucocytic infiltration;
  • reducing exudation and proliferation phases;
  • the lack of formation of scar tissue;
  • preserving the anatomical and functional usefulness of the cervix.


It should be noted the advantage of the photosensitizer FOTODITAZIN" in the form of a gel in comparison with a intravenous solution:

  • it's not require restriction light mode;
  • eliminates the accumulation of the photosensitizer in the other organs and tissues with high proliferative activity that should be considered in cases of combination of the pathology of the cervix uterine with hysteromyoma, adenomyosis and other pathological processes accompanied by increased proliferative activity.



Photodynamic therapy in gynecology is sufficiently radical method, but at the same time attenuated, with preservation of anatomical and functional usefulness of the cervix and it is the drug of choice in the treatment of background and precancerous diseases of the cervix, especially in women of the reproductive period. Ease of implementation of the method and its effectiveness determines the appropriateness of use in practical healthcare.


PHOTODYNAMIC THERAPY OF BACKGROUND DISEASES AND DYSPLASIA OF CERVIX OF THE UTERUS

Indications:
  • Cervical ectopia
  • Cervical leukoplakia
  • Cervical endometriosis
  • Cervical retention cysts (Ovulae Nabothi)
  • Cervical dysplasia of grade I-II

Dermatology

Ministry of Health and Social Development of the Russian Federation approved and allowed the wide spread use in medical practice, the following medical technologies which employ in dermatology the topical agent Fotoditazin :

PHOTODYNAMIC THERAPY OF PSORIASIS AND SKIN DERMATOSIS

Indications:
  • Psoriatic rash on patients skin with psoriasis
  • Intolerance of medical agents
  • Patients refusal from conventional therapy


PHOTODYNAMIC THERAPY IN CORRECTION OF INVOLUTIONAL SKIN CHANGES

Indications:
  • Skin papilloma
  • Skin keratosis
  • Structural changes of epidermis and derma
  • Ritidis
  • Elastosis
  • Dilated pores
  • Hypertrophic scar


PHOTODYNAMIC THERAPY OF ACNE VULGARIS

Indications:
  • Acne vulgaris of various localizations and intensity

Esthetics

Ministry of Health and Social Development of the Russian Federation approved and allowed the wide spread use in medical practice, the following medical technologies which employ in cosmetology the topical agent Fotoditazin :

Esthetics

PHOTODYNAMIC THERAPY For Acne Vulgaris

Indications:

  • Acne vulgaris of various severity levels and different localities



PHOTODYNAMIC THERAPY in Correcting Evolutionary Changes in the Skin

Indications:

  • Papilloma ;
  • Keratosis;
  • Structural changes in the epidermis and dermis;
  • Rhytide ;
  • Elastosis ;
  • Enlarged pores;
  • Hypertrophic scars;


PHOTODYNAMIC THERAPY of PSORIASIS and DERMATOSES

Indications:

  • Relieves psoriatic skin rashes;
  • Can be used on patient with intolerance to alternative medication;
  • Patients rejection to the traditional methods of treatment


The high efficacy of the drug is achieved due to the accumulation of the photosensitizer in the skin cell structures, which have differing outer membrane damage, old and abnormal cells, rapidly proliferating cells, and cells affected by viral or bacterial microflora.
The interaction of light energy, delivered to the cellular structures of the skin through the accumulation of the photosensitizer Fotoditazin, leads to the development of the photodynamic process in the cellular structures, destroying the basic cellular structures (which includes the development of the apoptosis processes) , inducing the growth of young healthy skin cells (the fibroblast type) . In addition, the interaction of plasma protein, photosensitizer and light energy enhances the humeral immunity due to the synthesis of cytokines and interleukins.

Working with the Fotoditazin agent is simple and painless to patients. The application process involves cleaning the patients skin and then applying , to the outer cleaned surface skin, the topical agent Fotoditazin . In 20 minutes, the topical agent must be washed off thoroughly. Tune the laser device to a continuous mode; apply a special dispersing nozzle on the laser device. Using a 662nm wavelength, carry out the irradiation on the, previously mentioned, cleansed skin surface area. Once the irradiation is completed, administer a massage along the muscular frame of the affected area and apply a soothing moisturizer.

In addition, the gel "FOTODITAZIN" can be employed in cutaneous rejuvenation. The course of treatments includes one or several procedures, depending on the condition of the skin, with an interval of 3 days.
Cutaneous rejuvenation is due to the fact that, after PDT, the skin regenerates better. The old cells die off quickly, in their place, form new and healthy, improves blood circulation, promotes the production of collagen, the skin gets more nutrition and is gradually recovering.

PDT promotes:

  • The reduction of pores and sebaceous glands;
  • Smoothing of the skins texture;
  • Wrinkles Reduction;
  • Elimination of facial sagginess;
  • Treatment of acne and maintenance of acne-free skin;
  • Improves the oval shape of the face.


Esthetics Esthetics

Oncology

Photodynamic Therapy in oncology

Photodynamic therapy in oncology is relatively young (about 20 years) direction of drug-instrumental anticancer therapy. The greatest experience gained with this method in the treatment of tumors of the head and neck, stomach, esophagus, female reproductive organs, lung and bronchus, prostate cancer, skin cancer. Considerably less experience with melanoma, primary tumors and liver metastases, intestines and pancreas.

The high selectivity of tumor lesions in photodynamic therapy in oncology allows a minimum injure surrounding healthy tissue, which leads to high functional outcome of treatment and distinguishes it from traditional therapy and absence of serious local and systemic complications.

Photodynamic therapy in oncology induces necrosis and apoptosis of tumor cells.

Photodynamic therapy with the drug "FOTODITAZIN" in oncology led to the development of therapeutic effect in all cases. The lack of effect was noted. During the treatment according to the radical program in patients with primary and recurrent skin cancer was achieved the complete resorption in 90% of cases, the treatment of malignant tumors of the internal organs were found complete and partial resorption in 70% of cases.

Health and Social Development Minister of the Russian Federation were approved and allowed for widespread use in practical public health following medical technology and use the drug "FOTODITAZIN":

PHOTODYNAMIC THERAPY OF LUNG CANCER

Indications:
  • Central inoperable lung cancer
  • Recurrence of lung cancer after surgical and combined therapy
  • Stenosing bronchus cancer
  • In case of contra-indications for surgery and ineffectiveness of chemo- and radiation therapy
  • Palliative purpose for improvement of quality of life of cancer patients


PHOTODYNAMIC THERAPY OF BASAL CELL CARCINOMA AND SKIN KERATOSIS

Indications:
  • Basal cell carcinoma and skin keratoses of various localizations (T1-T4, Mo)
  • Patients refusal from conventional therapy
  • Tumors, resistant to standard methods of treatment
  • High risk of complications after radiation therapy and surgery in older patients and patients with somatic disorders
  • Patients who cannot receive conventional therapy owing to different reasons
  • Recurrences, residual tumors and tumors with the infiltration depth of more than 0.5 mm
  • Infiltrating ulcerous forms of basal cell carcinoma of different localizations
  • Palliative purpose for improvement of quality of life of cancer patients



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